Sickle Cell Trait Protects Against Plasmodium falciparum Infection
نویسندگان
چکیده
منابع مشابه
Sickle cell trait protects against Plasmodium falciparum infection.
Although sickle cell trait protects against severe disease due to Plasmodium falciparum, it has not been clear whether sickle trait also protects against asymptomatic infection (parasitemia). To address this question, the authors identified 171 persistently smear-negative children and 450 asymptomatic persistently smear-positive children in Bancoumana, Mali (June 1996 to June 1998). They then f...
متن کاملProtection afforded by sickle-cell trait against subtertian malareal infection.
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Background: Sickle cell disease (HbSS) is a major health problem in Nigeria and ma-laria has been implicated as a leading cause of morbidity/mortality in sickle cell disease patients. Few reasons were put forward to explain the observed morbidity/mortality of HbSS subjects due to Plasmodium falciparum (P. falciparum) malaria. Objectives: To determine the level of immunoglobulin classes (IgM, Ig...
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We have shown that the haemolytic activity of fatty acids may be implicated in the destruction of erythrocytes by malaria parasites (Laser et al., 1975a,b). Under normal conditions free fatty acids are buffered by albumin in the serum and haemoglobin within the erythrocyte. During a malarial infection, however, the presence of the Plasmodium leads to an increase in both serum and erythrocyte fa...
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Insect-reared Anopheles gambiae were experimentally fed with the blood of naturally infected human volunteers carrying gametocytes of Plasmodium falciparum. Infection of at least one mosquito was successful in 86 experiments. For these gametocyte carriers, the hemoglobin types studied were AA (normal, n = 77), AS (heterozygous sickle cell, n = 8), and SS (homozygous sickle cell, n = 1). The mea...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2012
ISSN: 1476-6256,0002-9262
DOI: 10.1093/aje/kws323